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稀鑒酸 또는 重曹가 Vitamin B12의 吸收에 미치는 影響

The Effect of the Dilute Hydrochloric Acid or Sodium Bicarbonate on the Absorption of Orally Administered Co60-Vitamin B12 in Rats

대한의학협회지 1964년 7권 4호 p.339 ~ 344
張益洙, 강반, 呂雄淵,
소속 상세정보
張益洙 (  ) - 慶北大學校 生理學敎室
강반 (  ) - 慶北大學校 生理學敎室
呂雄淵 (  ) - 慶北大學校 生理學敎室

Abstract


Since successful synthesis of radioactive vitamin B_(12) was reported by Chaiet et at in 1950, the gastrici ntrinsic factor activity have been extensibly studied. However, the nature of the intrinsic factor and mechanism of vitamin B_(12) absorption from the intestinal canal have not been clearly found yet. Andthe exact function of the gastric acid on the intrinsic factor is also obscure even the fact that the intrinsic factor has some dependence with the gastric acid is well known.
Present study describes on the effect of orally administered dilute hydrochloric acid and sodium bicarbonate sollutions on the absorption of Co^(60)_vitaminB_(12)in rats.
The rats were divided into 3 groups and the first group was administered orally 1 ml, of Co^(60)-vitaminB_(12) (48.3 ㎍., 0.1 c.) and 3 ml. of 0.16N hydrochloric acid solution successibly. The second group was administered 1 ml. of Co^(60)_vitamin B_(12) and 3 ml. of0.16 N sodium bicarbonate solution, and the third group was administered 1 ml. oi Co^(60)_vilamin B_(12) and3 ml, of normal saline as control.
The rats´ stool was collected every day for 3 days and the liver and kidney were removed at 3, 6 and9th day after administration of Co^(60)_vitamin B_(12)and acid or alkali or saline for the determination of Co^(60)-vitamin B_(12).The contents of Co^(60)_vitamin B_(12) were counted with well type scintillation counter.
The results were summarized as follows:
The fecal excretion of Co^(60)_vitamin B_(12) showed a Vitamin tendency of slight increase in sodium bicarbonate administered group and significantly decreased in hydrochloric acid administered group comparing with control group.
The content of Co^(60)-vitamin B_(12) in the liver and .kidney, when administered with dilute sodium bicarbonate solution was essentially the same as that of control group. Whereas the contents of Co^(60)-vitaminB_(12) in the liver and kidney, when administered with the dilute hydrochloric acid., was markedly higher than that of control group.
These results indicate that orally administered dilute hydrochloric acid enhanced absorption of vitaminB_(12) from the intestinal canal and sodium bicarbonate solution has no significant effect on the absorption of vitamin B_(12)
With the above results, authors were impressed that orall administration of hydrochloric acid solution promotes the activity of gastric intrinsic factor. but neutralization of gastric acid with alkali solution does not inhibit the inherant actitity of the gastric intrinsic factor.

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