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一酸化炭素 Gas Pocket에 관한 硏究

GAS EXCHANGE IN CARBON MONOXIDE GAS POCKET

대한의학협회지 1964년 7권 11호 p.1067 ~ 1082
여웅연,
소속 상세정보
여웅연 (  ) - 경북대학교 의과대학 생리학교실

Abstract


This study describes on the 9as exchange in carbon monoxide gas Pocket. High concentration of carbon monoxide was injected into the subcutaneous gas pocket, including multiseptal gas pocket, and peritoneal cavity of albino rats.
The changes in volume and composition of pocket gases were determined at the definite interval of time separately in different groups of rats.
To observe the vasomotor effects on the gas exchange. some vasomotor drugs, bosmin (containsepinephrine and norepinephrine) and histamine, were injected into some gas pockets.
After analysing the results the following facts were concluded :
1. When high concentration of carbon monoxide (89%) was injected into subcutaneous gas Pockets, the slope of CO elimination curve was very steep immediately after the injection and decreased gradually thereafter following the typical exponential curve and almost leveled off at 0.53% in CO concentration after 24 hours.
The mean absorption rate of CO during the first 2hours was calculated as 1.05 × 10-^(4)ml./min. mm,Hg.
2. Absorption rate of CO from subcutaneous gas pocket in which bosmin had been injected was decreasea markedly and from the gas Pocket in which histamine had teen injected was increased significantly.
3. Absorption rate of CO from peritoneal cavity after injection of high concentration of CO was increased. more than two-fold comparing with that of sutcultaneous gas Pocket, i.e.. 1.23 × 10-^(4) ml./min. mm. Hg.
The increased absorption rate CO from peritoneal cavity and histamine injected subcutaneous CO gas pocket was attributed to the increased absorption surface, increased blood flow and decreased thickness of diffusion barrier.
4. Oxygen concentration in the subcutaneous CO gas pocket increased gradually and showed the peak value of 10.35% at the 6th tour after injection ofCO gas into the pocket. and thereafter decreased again .
Oxygen concentration in the perioneal CO gas pocket was higher as much two-fold as that in sub cutaneous CO gas Pocket within the first 2 hours.
Oxygen concentration was lower in bosmin injected subcutaneous CO gas pocket and was higher in histamine injected and multiseptal subcutaneous COgas pocket than that of air injected gas Pocket.
5. The higher concentration of O_(2) in various COgas pockets was attributed to the elevated p0_(2) in the blood perfusing the pocket wall due to increased liberation of free 0_(2) from the hemoglobin after combining the CO with hemoglobin.
6. Carton dioxide concentration in both subcutaneous and peritoneal CO gas pochet was lower significantly than that of all injected gas potket. And such decreased concentration in CO_(2) was attributed to inhibition of tissue cytochrome oxidase by high concentration of CO and hyperventilation Possibly by CO induced hypoxia.
7. Absorption of CO from gas Pocket is predominantly diffusion limiting process as in 0_(2) absorption from gas pccket.

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