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醋酸에 依한 食道腐蝕症에 있어서 肺臟의 病理組織學的硏究

The Histopathological Studies on the Lung in the Experimental Corrosive Esophagitis due to Acetic Acid

민건식,
소속 상세정보
민건식 (  ) - 제오육군병원 이비인후과

Abstract


Even though the incidence of corrosive esophagitis has been decreasing in the last -decade, there are still a significant number of canes of suicidal ingestion of lye and acids in the adult and accidental ingestion in children in Korea.
The purpose-of-this experiment is to study the histopathological changes in the lung,g which occur in the corrosive esophagitis experimentally produced by acetic acid.
The esophagus of averaging two Kg. weighted -rebbits were ingested with 3.0 cc of a 3.0% of acetic acid by the pipet through the esophagoscope, and the following macroscopic findings were observed.
1) Pulmonary congestion, bleeding, thrombosis and edema are the initial findings which progress in intensity to the 3rd day. At this time bronchopneumonia set in.
2) At about I week they are followed with emphysematous changes in the lung which persist relatively for a long time.
3) At the end of the 5th week it shows relatively normal lung, structure.
From the above observations we can suggest a great amount of acid is-absorbed directly into the blood stream and thus produces parenchymal damage in the lung which terminates in pneumonia. Further it can be stated that the symptoms which persist for a considerable length of time, are due to reabsorption of necrotic products from the stomach and intestine.

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