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급성 저음역 감각신경성 난청에서 호중구-림프구 비율 및 혈소판-림프구 비율의 의의

The Significance of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Acute Low Tone Sensorineural Hearing Loss

대한이비인후과학회지-두경부외과학 2020년 63권 12호 p.558 ~ 563
김건호, 김병훈, 이승열, 정재호, 변하영, 이승환,
소속 상세정보
김건호 ( Kim Keon-Ho ) - Hanyang University College of Medicine Department of Otolaryngology-Head and Neck Surgery
김병훈 ( Kim Byung-Hun ) - Hanyang University College of Medicine Department of Otolaryngology-Head and Neck Surgery
이승열 ( Lee Seung-Yeol ) - Hanyang University College of Medicine Department of Otolaryngology-Head and Neck Surgery
정재호 ( Chung Jae-Ho ) - Hanyang University College of Medicine Department of Otolaryngology-Head and Neck Surgery
변하영 ( Byun Ha-Young ) - Hanyang University College of Medicine Department of Otolaryngology-Head and Neck Surgery
이승환 ( Lee Seung-Hwan ) - Hanyang University College of Medicine Department of Otolaryngology-Head and Neck Surgery

Abstract


Background and Objectives : Acute low tone sensorineural hearing loss (ALHL), an acuteonsethearing loss limited to low tone, was thought to be a subtype of sudden sensorineural hearingloss (SSNHL) but also considered as new disease entity because it shows quite different symptoms,progress, and prognosis. More recently, however, it is thought that SSNHL results fromchronic inflammation and thrombosis. Some studies have reported that neutrophil-to-lymphocyteratio (NLR) and platelet-to-lymphocyte ratio (PLR) were high in SSNHL patients, and thatthey were significant as prognostic factors. The aim of this study was to evaluate the significanceof NLR and PLR in ALHL.

Subjects and Method : From January 2009 to June 2019, we retrospectively studied 58 patientswho were diagnosed with ALHL. Characteristics of patients such as sex, age, symptomsand signs, the results of serologic test and pure tone audiometry were evaluated for recoveryand for recurrence. Also, we selected 58 people with the same age as control group.

Results: A total of 167 patients were identified, of whom a half was diagnosed with ALHL andthe other half with were the control group. Among the 58 patients, the mean age was 38.0±14.5years old, and 10 (17.2%) patients were male and 48 (82.8%) patients were female. Among thepatients, 35 (60.3%) were hospitalized and 23 (39.7%) were outpatients. For recovery, 38 (65.5%)patients fully recovered while 11 (19.0%) partially recovered, and 9 (15.5%) did not recover. Additionally,16 (27.6%) patients recurred later with similar symptoms. Between the patient groupand control group, there were significant differences in the total white blood cell count, neutrophilcount, NLR and PLR (p=0.015, 0.001, 0.002, and 0.025), but there was no significant differencesbetween the recovery group and non-recovery group in any laboratory findings. Also, NLRand PLR showed no significant differences between the recurred group and non-recurred group.

Conclusion : NLR and PLR in ALHL patients were relatively high compared to the controlgroup, but there were no significant differences between the recovery group and non-recoverygroup. Furthermore, there was no correlation between NLR and PLR with recurrence. HighNLR and PLR values in ALHL patients might reflect its inflammatory etiology, but there is lackevidence for them to serve as prognostic factors.

키워드

Hematologic test; Pathophysiology; Sensorineural hearing loss

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