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치매 환자를 위한 청각 검사의 체계적 문헌 고찰 및 메타 분석

Auditory Function Testing for Types of Dementia: Systematic Reviews and Meta-Analysis

Park Si-Hun, 한우재, 공태훈, 서영준, 한재현, 김태희,
소속 상세정보
 ( Park Si-Hun ) - Hallym University College of Natural Sciences Laboratory of Hearing and Technology
한우재 ( Han Woo-Jae ) - Hallym University College of Natural Sciences Laboratory of Hearing and Technology
공태훈 ( Kong Tae-Hoon ) - Yonsei University Wonju College of Medicine Department of Otolaryngology-Head and Neck Surgery
서영준 ( Seo Young-Joon ) - Yonsei University Wonju College of Medicine Department of Otorhinolaryngology-Head and Neck Surgery
한재현 ( Han Jae-Hyun ) - Yonsei University Wonju College of Medicine Department of Psychiatry
김태희 ( Kim Tae-Hui ) - Yonsei University Wonju College of Medicine Department of Psychiatry

Abstract


It is acknowledged that there is a negative relationship between dementia and auditory functionin older adults. This study conducted a systematic review and meta-analysis based on the dataof audiologic testings from patients with neurodegenerative diseases in terms of auditory eventrelatedpotentials and central auditory processing tests, while focusing on Alzheimer’s disease(AD), dementia with Lewy bodies (DLB), and Parkinson’s disease dementia (PDD). A total of34765 articles were retrieved from the seven electronic databases. After being screened by Participants,Index test, Control, Outcomes, Study design (PICOS) criteria, 129 articles for ADwere included and then 72 articles were applied to the meta-analysis. However, five and six articleswere systematically reviewed for the auditory functions of DLB and PDD, respectively,due to a small number of articles. The results of meta-analysis showed a significant differencebetween patients with AD and age-matched normal subjects, for N200 and P300 latency, P300amplitude, and the behavioral central auditory processing tests, although there was a high heterogeneity.
On the other hand, the systematic review indicated that the results of mismatchnegativity test might distinguish auditory performance of DLB patients from that of PDD.
Furthermore, for P300 amplitude, anterior to posterior distribution of brain resulted in meaningfuldifference of auditory function between AD and DLB patients. In sum, current reviewstudy suggests that lesion and degree of auditory (dys)function may be different depending onthe type of dementia, although future research should be followed.

키워드

Alzheimer’s disease; Auditory event-related potentials; Central auditory processing; Dementia with Lewy bodies; Parkinson’s disease dementia

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