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Early use of everolimus improved renal function after adult deceased donor liver transplantation

대한이식학회지 2021년 35권 1호 p.8 ~ 14
Lee Seo-Hee, 김종만, 김상진, 유진수, 최규성, 조재원,
소속 상세정보
 ( Lee Seo-Hee ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Surgery
김종만 ( Kim Jong-Man ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Surgery
김상진 ( Kim Sang-Jin ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Surgery
유진수 ( Rhu Jin-Soo ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Surgery
최규성 ( Choi Gyu-Seong ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Surgery
조재원 ( Joh Jae-Won ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Surgery

Abstract


Background: Tacrolimus (TAC) is a main therapy for liver transplantation (LT) patients, but it has side effects such as chronic nephrotoxicity that progressively aggravate renal function. The purpose of this study was to retrospectively compare the renal function between a TAC group and a combination of everolimus and reduced TAC (EVR-TAC) group after deceased donor liver transplantation (DDLT).

Methods: The study comprised 131 patients who underwent DDLT between January 2013 and April 2018 at our institution. They received TAC or EVR-TAC after DDLT. Everolimus (EVR) was introduced between 1 and 6 months after DDLT.

Results: Thirty-six of 131 patients (27.5%) received EVR-TAC. The incidence of chronic kidney disease (CKD; estimated glomerular filtration rate, <60 mL/1.73 m2) in the EVRTAC group was higher than in the TAC group (25% vs. 8.4%; P=0.019). Increasing serum creatinine (n=23, 63.9%) was the most common cause for adding EVR to treatment of the posttransplant patients. There were no statistical differences in acute rejection and CKD between the two groups. The TAC trough level was significantly lower in the EVRTAC group than in the TAC group, and the renal function of the EVR-TAC group was worse than that of the TAC group until 1 year after DDLT. However, the renal function of the EVRTAC group improved and became similar to that of TAC group at 3 years posttransplant.

Conclusions: The present study suggests that EVR should be introduced as soon as possible after DDLT to reduce exposure to high doses of TAC to improve the renal function.

키워드

Renal insufficiency; Immunosuppression; Calcineurin inhibitors

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