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Familial Benign Chronic Pemphigus(Hailey and Hailey)의 1例

A Case of Familial Benign Chronic Pemphigus(Hailey and Hailey)

대한피부과학회지 1962년 2권 2호 p.47 ~ 52
서치균,
소속 상세정보
서치균 (  ) - 국립중앙의료원 피부과

Abstract


A case of familial benign chronic pemphigus in 28 year old male is described which is the first case reported in Korea, and the literature is reviewed.
The grandmother had similar symptoms and the 52 years old father has suffered from the same trouble since puberty.
The patient´ s lesions were vesicular, pustular, and crusted patches with erosions which have been persistent since 12 years of age, mainly affecting lateral and posterior sides of the neck, axillary and inguinal regions, lower abdomen, and popliteal fossae symmetrically.
Moderate itching was associated with the lesions, which were worse .in summer and better in winter.
Staphylococcus aureus and β-hemolytic streptococcus were cultured from the lesions and found to be sensitive to aureomycin, terramycin and erythromycin.
Biopsy findings showed hyperkeratosis, irregular acanth:)sis, multilocular suprabasal clefts or bullae with extensive acantholysis. Villi formation was also noted. Dyskeratotic changes were present but no mitosis was seen.
Local application of 1% hydrocortisone ointment gave temporary improvement but no effect was noted with systemic prednisolone, aureomycin, sulfadrugs, and vitamin A & D, or local treatment with antibiotic ointments.

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