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Sporotrichum의 動物移植에 關한 實驗的硏究

Experimental Study on Sporotrichosis by Inoculation in Rats

대한피부과학회지 1967년 6권 1호 p.19 ~ 24
이윤재,
소속 상세정보
이윤재 (  ) - 서울대학교 의과대학 피부과학교실

Abstract


Sporotrichosis is a chronic granulomatous mycosis caused by Sporotrichum species.
In Korea, Kim et al. had reported two cases of cutaneous sporotrichosis involving upper extremities for the first time in 1960.
They had determined their strain to be similar to a variant of S.beuermanni by culture. These Kim´s strain has inoculated into the peritoneum of rats in order to -observe its
pathogenicity, virulence and course by examining the macroscopic and microscopic findings. The conclusion were as follows:
1. Rats were inoculated intraperitoneally and killed at intervals of 1% 20, 30, 40 and 50 days and followed by postmortem examination,
2. Macroscopic findings:
At twelve days on lesions were observed. At 20 to 50 days all showed grayish brown lymphnodules varying in size, which were disseminated on the mesentery, omentum, peritoneum and inguinal region.
On lung, liver, spleen and kidney, various changes i. e.; congestion, necrosis and degenerative changes were noted at 34 to 40 days after inoculation.
3. Microscopic findings:
a. Most nodules were characterized by three distinct zones, i. e.; central suppurative, J middle tuberculoid, and peripheral syphiloid zones.
b. Visceral organs showed the following pathological changes varying with the duration of infection; diffuse hepatic necrosis, bronchitis and pneumonitis, splenitis and degenerative changes in the kidney.
c. Microorganisms could found in tissue by PAS stain. Its frequency rate shows 52% in lymphnodules and 16y in visceral organs.
4. For some unknown reasons isolations of the organisms by culture was successful only from 3 rats.

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