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수종 (數腫) 의 항히스타민제가 조직비반세포에 미치는 영향 (影響) 에 관한 실험적 (實驗的) 연구

Experimental Study on The Role of Various Antihistaminics to Tissue Mast Cell Changes Elicited by Ultraviolet Ray Inflammation

대한피부과학회지 1969년 7권 1호 p.9 ~ 24
허원, 김성환,
소속 상세정보
허원 ( Houh Won ) - 서울대학교 의과대학 피부과학교실
김성환 ( Kim Sung-Hwan ) - 서울대학교 의과대학 피부과학교실

Abstract


In order to elucidate the mast cell changes challenged by various antihistaminic preparations and its role to the mast cells challenged by inflammation, male albino rats weighing 120130gm were used for this investigations.
Benadryl hydrochloride, Phenergan hydrochloride and Chlor-Trimeton maleate were .choosed for antihistaminic challengers and ultraviolet ray was irradiated for an inflammatory challenger.
1. When rats were challenged by various antihistaminics the numbers of mast cell reached -to the least after 2 days and later followed by an increasing mast cell numbers.
2. The mast cell changes were severer in order of Phenergan hydrochloride, Benadryl hydrochloride and Chlor-Trimeton maleate.
3. Degranulated mast cell was proportionally increased as the numbers of mast cell -decrease after being chalinged by antihistaminics and also it was decreasing when the numbers of mast cell were re-increasing (Rebound phenomena).
4. The mast cell changes were severer proportionally when inflammation was elicited by ultraviolet ray inspite of antihistaminics injections tha n the former solely antihistamine .challenged experiments.
5. The mast cell changes were severer in order of Phenergan hydrochloride. Benadryl hydrochloride and Chlor-Trimeton maleate when ultraviolet ray inflammation was elicited.
6. When inflammation was elicited by ultraviolet ray the other parts non-irradiated tissue mast cell numbers was also challenged severely, yet comparatively less than that site of direct irradiation.

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