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交感神經系藥物의 개구리皮膚 Melanophore濃縮機轉에 關한 硏究 The Influences of Sympathomimetic Amines on Melanophores of the Frog Skin

대한피부과학회지 1971년 9권 2호 p.9 ~ 14
조정구,
소속 상세정보
조정구 (  ) 
연세대학교 의과대학 피부과학교실

Abstract


The chromatic activity and potency of various sympathomimetic amines were examined in the normal frogs using the Hogben and Slome Index as a -simple. method for measuring melanophore responses.
All the sympathomimetic amines tested in this experiment exhibited the marked aggregation of melanophores. Among these amines, the order of potency in producing the melanophoreaggregation was catecholethylamine derivatives (epinephrine and i. ;proterenol)) m.onohydroxyphenylethylamine derivative (tyramine) with exception of phenylephrine) nonhydroxyphenyletyhlamine derivatives (ephedrine and propadrine). Of catecholethylamine derivatives, the melanophore-aggregating activity of epinephrine was more potent than that of isoproterenol. On the other hand, phenylephrine belong to the monohydroxypheny lethylamine derivatives was the least potent agent than the other amines tested.

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