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밤꽃 抽出物의 抗絲狀菌 作用 A Study of Antifungal Activity with Castanea Crenata Flos.

대한피부과학회지 1976년 14권 2호 p.91 ~ 95
李昌雨, 金洪植,
소속 상세정보
李昌雨 (  ) 
서울대학교 醫科大學 皮膚科學敎室

金洪植 (  ) 
서울대학교 醫科大學 皮膚科學敎室

Abstract


There are many herbs used in the treatment of dermatophytosis as home medicine and Castanea crenata Flog (C.C.F.) is one of that used in Kyung gi-do district.
With that regard we tried to examine in vitro antifungal activity of the C.C.F. with its water extract and alcohol extract as the test materials.
Until row many authors have studied the antifungal activity with several plant extracts, as like the alcohol extracts of Zanthoxylum piperatum Fructus and Berberis Korea palibin or Fennel oil, and reported that these plant extracts or essential oil have good antifungal activities in vitro and in vivo. On that they said that the principal fractions those have strong fungistatic activity were all alikely the fatty acids chemically similar with the well known undecylenic acid.
At this in vitro experiment the extracts of C.C.F. were diluted serially in the Sabouraud´s dextrose agar and certain portions of fungi (the strains of Trichophyton (Tr.) mentagrophytes and Tr. rubrum) were transplanted into each medium containing different concentrations of test materials then observed its growth for 2 weeks at room temperature. After that we measured the sizes of colony grown in various conditions and compired with that of the normal medium to determine the fungistatic effectiveness.
As the result, in the view of the colony sizes, Tr. mentagrophytes and Tr. rubrum equally revealed marked inhibition of its growth only in the media with water extract over the concentration of 10mg/ml in the medium, and the critical fungistatic dilution was 20 mg/ml.
We could not identified the principal fraction in the water extract of C.C.F.which exhibited antifungal activity.
In the comparison of the critical fungistatic dilution with the alcohol extract of Zanthoxylum piperatum Fructus and Fennel oil, water extract of C.C.F. required ten fold higher concentration for the same effect. However in regarding the utilizing habits of C.C.F. in home medicine, as topical wet dressing with water boiled solution, we might expect its effect practically.
Now there are problems to be investigated about the chemical natures and physical properties of the C.C.F. an 1 for the antifungal fractions of it, in addition further in vivo study we thought would be interesting.

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