잠시만 기다려 주세요. 로딩중입니다.

BCG 예방 접종 후 발생한 특이 피부 이상반응에 대한 임상 연구

Clinical Study of Specific Cutaneous Complications after BCG Vaccination

대한피부과학회지 2020년 58권 7호 p.453 ~ 458
원상현, 신기혁, 김우일, 양민영, 이원구, 김훈수, 김병수, 김문범, 고현창,
소속 상세정보
원상현 ( Won Sang-Hyeon ) - Pusan National University School of Medicine Department of Dermatology
신기혁 ( Shin Ki-Hyuk ) - Pusan National University School of Medicine Department of Dermatology
김우일 ( Kim Woo-Il ) - Pusan National University School of Medicine Department of Dermatology
양민영 ( Yang Min-Young ) - Pusan National University School of Medicine Department of Dermatology
이원구 ( Lee Won-Ku ) - Yonsei University College of Medicine Department of Dermatology
김훈수 ( Kim Hoon-Soo ) - Pusan National University School of Medicine Department of Dermatology
김병수 ( Kim Byung-Soo ) - Pusan National University School of Medicine Department of Dermatology
김문범 ( Kim Moon-Bum ) - Pusan National University School of Medicine Department of Dermatology
고현창 ( Ko Hyun-Chang ) - Pusan National University School of Medicine Department of Dermatology

Abstract


Background: Bacille Calmette-Guerin (BCG) vaccination has been widely used to prevent severe infections caused by Mycobacterium tuberculosis. Although BCG vaccination is generally safe, some cutaneous complications may occur. However, cutaneous complications related to BCG infection have been rarely investigated in Korea.

Objective: This study aimed to investigate the clinical characteristics of cutaneous complications following BCG vaccination in Korean patients.

Methods: We identified 18 patients with cutaneous complications following BCG vaccination in the Pusan National University Hospitals (Busan and Yangsan) from 2002 to 2019. Clinical manifestations and course were examined by the review of medical records and photographs.

Results: Among BCG-vaccinated persons, 18 patients manifested with BCG-specific cutaneous complications. The mean age of the patients was 10.6±10.1 months, and 10 (55.6%) were female. The specific cutaneous complications following BCG vaccination were local abscess (7, 38.9%), lymphadenitis (4, 22.2%), BCG reactivation in incomplete Kawasaki disease (4, 22.2%), tuberculid (3, 16.7%), and scrofuloderma (1, 5.6%). Disseminated BCG infection was detected in 2 brothers (11.1%) who had an immunocompromised state and a family history of BCG complication.

Conclusion: Specific cutaneous complications after BCG vaccination are rare, but may occur in various manifestations.

키워드

Mycobacterium bovis; Kawasaki disease; Vaccination

원문 및 링크아웃 정보

등재저널 정보