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여성 외음부에 발생한 경화 위축성 태선에 대한 임상 및 병리조직학적 고찰

A Clinical and Histopathological Study of 25 Cases of Vulvar Lichen Sclerosus et Atrophicu

대한피부과학회지 2020년 58권 10호 p.643 ~ 649
권창일, 김동출, 김지연,
소속 상세정보
권창일 ( Kwon Chang-Il ) - Gyeongsang National University School of Medicine Department of Dermatology
김동출 ( Kim Dong-Chool ) - Gyeongsang National University Hospital Department of Pathology
김지연 ( Kim Chi-Yeon ) - Gyeongsang National University School of Medicine Department of Dermatology

Abstract


Background: Lichen sclerosus et atrophicus is an uncommon, benign, chronic lymphocyte-mediated inflammatory dermatosis that occurs mainly in the genital area. It causes substantial discomfort and morbidity, mostly in adult women.

Objective: To investigate the clinicopathological characteristics of patients with vulvar lichen sclerosus et atrophicus.

Methods: We retrospectively reviewed the clinical and histopathological features of 25 patients diagnosed with vulvar lichen sclerosus et atrophicus, who visited the dermatologic department between January 2009 and June 2017.

Results: The average age was 54.2 years, and the disease duration was mostly less than 1 year. The major clinical features were diffuse patch, followed by diffuse plaque and multiple macules. It often presented with diabetes mellitus, thyroid disease, and hypertension. Itching was the most common symptom, followed by pain and burning sensations. Histopathological findings were hyperkeratosis with follicular plugging; atrophy and loss of rete ridge elongation in the epidermis; liquefaction degeneration and keratinocyte necrosis in the dermo-epidermal junction; collagen fibers hyalinization; and infiltration of inflammatory cells in the dermis. Antihistamines and topical steroids were used in most cases for treatment.

Conclusion: Vulvar lichen sclerosus et atrophicus causes discomfort and diminishes the quality of life in older women. Early diagnosis and prompt treatment are vital in preventing disease progression and complications. This study will provide valuable data on vulvar lichen sclerosus et atrophicus to dermatologists.

키워드

Lichen sclerosus et atrophicus; Vulvar lichen sclerosus

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