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Neutrophilic Urticarial Dermatosis Accompanied with Bullous Lesions

대한피부과학회지 2020년 58권 10호 p.701 ~ 703
유대산, 김종훈, 김수찬,
소속 상세정보
유대산 ( Yoo Dae-San ) - Yonsei University College of Medicine Gangnam Severance Hospital Department of Dermatology
김종훈 ( Kim Chong-Hoon ) - Yonsei University College of Medicine Gangnam Severance Hospital Department of Thoracic Surgery
김수찬 ( Kim Soo-Chan ) - Yonsei University College of Medicine Gangnam Severance Hospital Department of Dermatology

Abstract


Neutrophilic urticarial dermatosis (NUD) clinically resembles urticaria but histopathologically represents a neutrophilic dermatoses. Affected patients develop erythematous macules, papules or slightly raised plaques lasting 24 to 48 hours. Histopathologic examination reveals an intense neutrophilic infiltration in the dermis with leukocytoclasia, but without fibrinoid necrosis of vessel walls. Clinical manifestations of NUD are similar to urticaria or Sweet’s syndrome, but it differs in that accompanying systemic symptoms like fever or arthralgia, and histologic features of dense neutrophilic infiltration in the dermis. A 69-year-old female patient presented with a one-day history of pruritic skin rashes and fever. Skin rashes appear erythematous patches and plaques on the whole body accompanied with multiple vesiculobullous lesions on both lower legs. Skin biopsy of lesion displayed interstitial neutrophilic infiltration in Indian file between collagen fiber, and leukocytoclasia. There were no clinical and laboratory findings that suspect of associated diseases. Herein, we report the first case of NUD developing vesiculobullous lesions.

키워드

Neutrophilic urticarial dermatosis; Neutrophilic dermatoses; Vesiculobullous lesion

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