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파킨슨병 in vivo 모델에서 한약재 및 기능성 식품의 항산화 효과에 대한 고찰

Review of the Antioxidant Effect of Herbal Material in In Vivo Parkinson’s Disease Models

대한한방내과학회지 2020년 41권 6호 p.993 ~ 1014
이기향, 전상우, 정민정, 김홍전, 장인수,
소속 상세정보
이기향 ( Lee Gi-Hyang ) - Woosuk University College of Korean Medicine Department of Internal Medicine
전상우 ( Jeon Sang-Woo ) - Woosuk University College of Korean Medicine Department of Internal Medicine
정민정 ( Jeong Min-Jeong ) - Woosuk University College of Korean Medicine Department of Pediatrics
김홍전 ( Kim Hong-Jun ) - Woosuk University College of Korean Medicine Department of Prescription
장인수 ( Jang In-Soo ) - Woosuk University College of Korean Medicine Department of Internal Medicine

Abstract


Objective: Parkinson’s disease (PD) is the second most common neurodegenerative disease after Alzheimer’s disease. Antioxidant stress and inflammatory reactions are important causes of neurodegenerative diseases and are major causes of PD. Many animal experiments have been aimed at treating PD using the antioxidant effects of various traditional medicines and dietary supplements. This review reports the research investigating the antioxidant effects of herbs in in vivo PD models.

Methods: The study consisted of a database search for articles related to PD and herbal treatments using the OASIS, NDSL, KTKP, Korean KISS, PubMed, Science Direct, CNKI, Wanfang, and J-STAGE databases. The search period was limited from the start of the search engine application to November 14, 2019. Studies were selected to confirm the antioxidant effects of herbal medicines in an in vivo PD model.

Results: Eighty-two studies were summarized for plant species, extracts (or compounds), animal models, neurotoxins, and functional results. The most frequently used herbal materials were Bacopa monnieri, Camellia sinensis, Centella asiatica, and Withania somnifera. MPTP and 6-OHDA were the most commonly used neurotoxins for inducing PD. Most studies confirmed an increased expression and activation of antioxidant enzymes and a decrease in oxidative stress. Herbal materials showed their antioxidant effects regardless of the order of treatment and confirmed their possible use as treatments for the prevention and treatment of neurodegeneration.

Conclusion: Many herbal medicines have antioxidant effects and are likely to be effective in delaying neurodegenerative damage by inhibiting or reducing oxidative stress by expression of antioxidant enzymes.

키워드

Parkinson’s disease; antioxidant effect; neurodegenerative disease; Chinese herbal drugs; medicinal plants; herb

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