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감초의 amorfrutin성분과 당뇨 치료 효과에 대한 고찰

Review on Amorfrutin of Licorice for Type2 Diabetes Mellitus

대한한방내과학회지 2020년 41권 6호 p.1078 ~ 1088
한주희, 허혜민, 정민정, 김홍전, 장인수,
소속 상세정보
한주희 ( Han Ju-Hee ) - Woosuk University College of Korean Medicine Department of Korean Medicine
허혜민 ( Heo Hye-Min ) - Woosuk University College of Korean Medicine Department of Korean Medicine
정민정 ( Jeong Min-Jeong ) - Woosuk University College of Korean Medicine Department of Pediatrics
김홍전 ( Kim Hong-Jun ) - Woosuk University College of Korean Medicine Department of Prescription
장인수 ( Jang In-Soo ) - Woosuk University College of Korean Medicine Department of Internal Medicine

Abstract


Objective: The purpose of this study was to investigate the effect of amorfrutin of licorice for Type2 diabetes mellitus.

Method: The PubMed, CNKI, Wanfang, OASIS, NDSL, J-STAGE, and CiNii databases were searched from the beginning of the search to September 20, 2020, with no limits on language. Extractions and selections from the literature were made by two authors. The study included in vivo experiments with amorfrutins in high-fat diet-induced obesity C57BL/6 mice and leptin receptor-deficient db/db mice and in silico studies.

Results & Conclusion: Four studies were finally selected. We confirmed that amorfrutin treatment considerably improved insulin sensitivity and glucose tolerance and reduced plasma insulin and glucose. Amorfrutins bind to and selectively activate Peroxisome Proliferator-Activated Receptor Gamma (PPARγ), which plays an important role in glucose metabolism. Amorfrutins also strongly bind to the glucagon receptor (GCGR) and work as antagonist. Using the amorfrutins from licorice could therefore be helpful in treating type2 diabetes mellitus.

키워드

amorfrutin; licorice; Type2 diabetes mellitus; PPARγ

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