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파킨슨병 관련 실험 연구에서 육계의 신경 보호효과에 대한 고찰

A Review of the Neuroprotective Effects of Cinnamon in Experimental Studies on Parkinson’s Disease

대한한방내과학회지 2020년 41권 6호 p.1089 ~ 1099
허혜민, 한주희, 정민정, 김홍전, 장인수,
소속 상세정보
허혜민 ( Heo Hye-Min ) - Woosuk University College of Korean Medicine Department of Korean Medicine
한주희 ( Han Ju-Hee ) - Woosuk University College of Korean Medicine Department of Korean Medicine
정민정 ( Jeong Min-Jeong ) - Woosuk University College of Korean Medicine Department of Pediatrics
김홍전 ( Kim Hong-Jun ) - Woosuk University College of Korean Medicine Department of Prescription
장인수 ( Jang In-Soo ) - Woosuk University College of Korean Medicine Department of Internal Medicine

Abstract


Objective: The purpose of this study was to investigate the effect of cinnamon on the treatment of Parkinson’s disease (PD) and to introduce its use in Korea.

Method: We searched the experimental studies in electronic databases (PubMed, CNKI, Wanfang, CiNii, J-STAGE, Science ON, and OASIS) using the key search terms “cinnamic acid”, “cinnamon”, “cinnamomum”, “Parkinson’s disease”, “Parkinson disease”, “Parkinsonism”, and “dopamine”. This study only involved experimental studies (in vivo and in vitro) that adopted cinnamon as a single administration and measured indicators relating to Parkinson’s disease, including parkin, tyrosine hydroxylase (TH), and dopamine.

Results: A Total of 11 literature studies were selected, and they all showed that treatment with cinnamon has a neuroprotective effect. Cinnamon activated neuroprotective factors and restored neurotransmitters and it reduced the rate of oxidative stress and inflammation in neurons. As a result, cell viability was upregulated, while cell apoptosis and neurodegeneration were downregulated. Five in vivo studies, through behavioral tests, also confirmed that cinnamon recovers locomotor function in PD models.

Conclusion: We identified that cinnamon is an effective neural protector and improves motor performance in behavioral testing in the experimental PD studies.

키워드

cinnamon; Parkinson’s disease; dopamine; review

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