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중의학 데이터베이스 (CAJ)를 이용한 급성백혈병의 한약치료에 대한 임상 연구 동향

Review of Clinical Studies for Herbal Medicine Treatment on Acute Leukemia - Focusing on Studies from the China Academic Journal (CAJ)

대한한방소아과학회지 2021년 35권 1호 p.48 ~ 62
김정은, 장진우, 박범찬, 김기봉, 천진홍,
소속 상세정보
김정은 ( Kim Jeong-Eun ) - Pusan National University School of Korean Medicine
장진우 ( Jang Jin-Woo ) - Pusan National University School of Korean Medicine
박범찬 ( Park Beom-Chan ) - Pusan National University School of Korean Medicine
김기봉 ( Kim Ki-Bong ) - Pusan National University School of Korean Medicine
천진홍 ( Cheon Jin-Hong ) - Pusan National University School of Korean Medicine

Abstract


Objectives The purpose of this study is to obtain knowledge from clinical studies conducted in China to examine the effectiveness of herb medicine in childhood acute leukemia.

Methods: We searched the randomized controlled trials (RCTs) with herbal medicine treatment on childhood acute leukemia from the ‘CAJ’, Chinese Academic Journal from China National Knowledge Infrastructure (CNKI). And then, demographic data, duration of illness, intervention, treatment period, outcome, adverse events, and composition of herbal medicine were analyzed for this study.

Result: 10 RCT studies were selected and analyzed. The control group were given western medicine therapy, the treatment group was given herbal medicine on the basis of the control group. The most commonly used herbal medicine were 淸熱解毒藥, 補氣藥, 補陰藥, 活血祛瘀藥 in ‘boosting vital force and driving out evil spirit (扶正祛邪)’ way to ‘relieve heat (熱毒)’ and ‘assist the vital force (正氣)’. In the treatment group, complete remission was significantly higher than control group and the decrease in TCM syndrome scores also showed significant effects. Adverse events were significantly lower in the treatment group.

Conclusions: Herbal medicine treatment on childhood acute leukemia can be suggested as a new treatment for children who have less response to the conventional therapy, and can supplement the limitations of the western medicine by increasing complete remission and reducing adverse events.

키워드

Acute leukemia; Herbal medicine; Child; Randomized Controlled Trial; Review

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