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증미오비탕이 Monosodium Iodoacetate 유발 관절연골손상에 미치는 영향

Effects of Jeungmiobi-tang on the Articular Cartilage Injuries Induced by Monosodium Iodoacetate in Rats

대한한의학회지 2020년 41권 3호 p.138 ~ 151
현재철, 정수현,
소속 상세정보
현재철 ( Hyun Jae-Cheol ) - Semyung University College of Korean Medicine Department of Rehabilitation medicine of Korean Medicine
정수현 ( Jeong Su-Hyeon ) - Semyung University College of Korean Medicine Department of Rehabilitation medicine of Korean Medicine

Abstract


Objectives: This study was carried out to investigate the protective effects of Jeungmiobi-tang on the articular cartilage injuries induced by monosodium iodoacetate in rats.

Methods: Twenty four rats were divided into three groups. Rats of normal group (n=8) were injected with 0.1 ml physiological saline into both knee joint cavities. In the rats of control group (n=8) and Jeungmiobi-tang group (n=8), Arthritis was induced by injecting with 0.1 ml monosodium iodoacetate (5 mg/ml) into both knee joint cavities. After the experiment, Gross and histopathological examinations on the knee joint were performed. The content of proteoglycan in articular cartilage and TNF-α and IL-1β in synovial fluid were also analyzed.

Results: Grossly, Injuries to the articular cartilage surface was observed weak in the Jeungmiobi-tang group compared to the control group. Proteoglycan content in the articular cartilage was significantly higher in the Jeungmiobi-tang group than in the control group. The chondrocyte score was significantly lower in the Jeungmiobi-tang group than in the control group.

Conclusion: According to these results, that Jeungmiobi-tang has protective effects on the articular cartilage injuries induced by monosodium iodoacetate in rats.

키워드

Jeungmiobi-tang; Monosodium iodoacetate; Articular cartilage injury; Proteoglycan; Osteoarthritis

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