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구충성빈혈(鉤蟲性貧血)에 관(關)한 연구(硏究)

The Study on the Ferrokinetics and Acquired Immunity in Repeated Hookworm Infections

대한핵의학회지 1967년 1권 2호 p.61 ~ 74
이문호, 이필웅,
소속 상세정보
이문호 ( Lee Mun-Ho ) - 서울대학교 의과대학 내과학교실
이필웅 ( Lee Pyl-Ung ) - 서울대학교 의과대학 내과학교실

Abstract


In order to confirm whether acquired immunity or resistance can be developed by the repeated hookworm infections, the 150 mature actively moving filariform ancylostoma duodenale larvae obtained from the severe hookworm anemia patients were orally given to 8 healthy volunteers in three divided doses, 50 in each, at 5 day interval. Also the hematological changes as well as several ferrokinetics using were done and were compared with 10 controls. The clinical symptoms and signs were checked every day for the first 3 weeks and then twice weekly until the end of the experiment. The appearance of the ova in the stool was examined by the formalin ether method and the ova was counted by the Stoll’s method. The following laboratory tests were done: 1) Red blood cell count, venous blood hematocrit(micromethod), hemoglobin count (cyanomethemoglobin method) were checked every 5 to 7 day interval. 2) Plasma iron concentration (Barkan’s modified method) was determined every 2 to 3 week interval. 3) Radioisotope studies: a) Ferrokinetics: Huff et al and Bothwell’s method were applied. Erythropoietic Index (% of normal)= of the gastrointestinal absorption of iron: Radioiron() balance b) Quantitative measurement method was applied. c) Determination of the plasma erythropoietin activity: Fried’s method was applied. Following were the results: 1) The serum iron level was lower. The red cell volume was decreased, but with relative increase of plasma volume. 2) The plasma iron disappearance time was accelerated and the plasma iron turnover rate was decreased. The red cell iron turnover rate was markedly increased, while all of the red cell iron concentration, circulating red cell iron. plasma iron pool were decreased. The daily iron pool turnover and red cell renewal rate were increased. 3) The erythropoietic index, erythropoietin activity and intestinal absorption of iron() were markedly increased. 4) The infectivity was which was lower than that observed in the single infection. 5) From these observations, it is concluded that the hookworm anemia is essentially iron deficieny in its origin and some immunity acquisition is possible with repeated infections.

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