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家兎를 利用한 放射線腎炎의 實驗的 硏究 An Experimental Study for Radiation Nephritis in Rabbits

대한핵의학회지 1972년 6권 2호 p.7 ~ 20
김명재,
소속 상세정보
김명재 (  ) 
서울대학교 의과대학 내과학교실

Abstract


Experimental radiation nephritis was produced in 15 rabbits by X-irradiation.
About 2, 000r (tissue doses) were given to both kidneys of a rabbit in 5 days. Other tissues and organs except both kidneys were protected with 2mm thickened lead plates.

5 weeks after the last irradiation, blood pictures, blood pressures, B.U.N., serum creatinine, Ca, Mg, Fe´ levels and serum erythropoietin activity of the irradiated rabbits were studied.
After finishing above studies, rabbits were sacrificed and both kidneys were removed and examined hi´stopathologically. Same laboratory and pathological ´ studies were performed-in 6 control , rabbits _
In this study, the author obtained following results.

1) Both kidneys of rabbit-is with experimental raditation nephritis `showed marked histopatbological changes, i.e.: renal tubules showed diffuse cloudy swelling, impacted intraluminal hyaline casts and ´ focal precipitation´s of lime salts on the ´tubular epithelium. ?_
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Diffuse interstitial fatty necrosis and various degrees of fibrotic infiltrations on the interstitium were also seen in association with focal lymphocytic infiltrations.

Hyaline degenerations were observed on the glomeruli and small vessels.

2) Experimental radiation ` nephritis rabbits showed marked lowering in R. B. CC counts, _ decreased , hemoglobin levels, low hematocrit values and leucopenia in comparison with those´ f control rabbits. (P<0.01). (Table 1 8 2).
3) Mild proteinuria were observed in experimental radiation nephritis in rabbits.

4) -The levels of B.U.N. and serum - creatinine increased in experimental radiation nephritis. ; -. -(P<0.01). (Table 1,3 & 4).
5) The levels of serum Ca and Mg Showed no statistical difference in comparison, with those of . control rabbits. (P>0.05). (Table 3 8 4).
6) No statistical correlations were observable between the levels of B.U.N. and HbE values. ´(7- -0.223).

No close correlations (r=-0.338) were noticed between the levels of B.U.N. and serum iron levels. 7) Erythropoietin activity (R.B.C. b9Fe Incorporation) was measured by the modified Fried method.
No change in its activity was noticed in radiation nephritis group comparing with that cf the control group. (P) 0.05). (Table 1, 3 & 5).
8) Carotid artery blood pressures showed also no difference. (P>0.05). (Table 1 & 2).

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