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초기계배 발생에 미치는 Serotonin의 영향에 관한 세포생물학적 연구

Cell Biological Studies of the EfEect of Serotonin on Chick Embryogenesis

한국동물학회지 1987년 30권 4호 p.432 ~ 444
최임순, 주충노, 최춘근, 주상옥, 김재원,
소속 상세정보
최임순 ( Choi Im-Soon ) - 연세대학교 이과대학 생물학과
주충노 ( Joo Chung-No ) - 연세대학교 이과대학 생화학과
최춘근 ( Choi Choon-Keun ) - 연세대학교 이과대학 생물학과
주상옥 ( Joo Sang-Ok ) - 연세대학교 이과대학 생물학과
김재원 ( Kim Jae-Won ) - 연세대학교 이과대학 생화학과

Abstract


Very early stage of chick embryo cultivated in the medium containing DLtryptophan by beaker method has been investigated in vitro morphologically using electron microscopy at cellular level and found that the development of tryptophan treated chick embryos corresponding to 18∼66 hrs incubation was impaired and york granule degradation was significantly delayed. It was also found that DNA, RNA and protein biosynthesis of tryptophan treated chick embryo was greatly lowered than those of control group. Conversion of L-tryptophan into serotonin was traced using 14C-L-tryptophan and found that 13.8cA of added radioactivity was recovered from serotonin formed during 18 hrs incubation and the amounts of serotonin formed were depend upon added amount of tryptophan in e99 yolk. It seemed that the serotonin formed from external tryptophan might inhibit the degradation of yolk granule by feedback mechanism, resulting in malformation of chick embryogenesis.

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