잠시만 기다려 주세요. 로딩중입니다.

Induction of Stress Proteins in the SCK Tumor Cells

한국동물학회지 1988년 31권 3호 p.157 ~ 164
강만식, 김경희,
소속 상세정보
강만식 ( Kang Man-Sik ) - 서울대학교 자연과학대학 동물학과
김경희 ( Kim Kyung-Hee ) - 서울대학교 자연과학대학 동물학과

Abstract


SCK tumor cells were exposed to heat shock or several sulihydryl-reacting agents such as iodoacetamide(IAA), zinc chloride(Zn), and 2-mercaptoethanol(ME). Stress proteins induced by these agents were examined and the relationship between the induction of stress proteins and the production of abnormal proteins was discussed. Based on the present experiments, two classes of intracellular pathways for the induction of stress proteins were defined; one dependent on and the other independent of protein synthesis. The presence of cycloheximide during the induction period blocked the formation of stress proteins in the cells exposed to Zn or ME, but not in those exposed to heat shock or IAA.Therefore, stress protein seems to be induced either by denaturation of pre-existing mature proteins (e.g., heat shock or IAA) or by newly synthesized abnormal proteins(e.g., Zn or ME). In conclusion, it is ilkely that the production of abnormal proteins by stresses triggers stress protein induction. In addition, it was found that the cells exposed to IISP and GRP inducers simultaneously responded to more strong stress among several stresses encountered.

키워드

SCK tumor cells ; Heat shock ; SH-reagents

원문 및 링크아웃 정보

등재저널 정보