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Relation of the Activities of Plasminogen Activator and Plasmin-like Protease with Malignant Behavior of Skin Tumor of Rats

한국동물학회지 1988년 31권 3호 p.185 ~ 190
Kee Yun, 박상철, 하두봉, 정진하,
소속 상세정보
 ( Kee Yun ) - 서울대학교 자연대학 동물학과
박상철 ( Park Sang-Chul ) - 서울대학교 의과대학 생화학교실
하두봉 ( Ha Doo-Bong ) - 서울대학교 자연대학 동물학과
정진하 ( Chung Chin-Ha ) - 서울대학교 자연대학 동물학과

Abstract


To investigate whether malignant behavior of skin tumor correlates with changes in the level of proteolytic activities in skin tumors, rats were treated with 7,12-dimethylbenzanthracene followed by photbor ester. Tumors induced upon the treatrnents exhibited more than 20-fold increase in the activity of plasminogen activator and about 3-fold of plasmin-like activity. as compared to those in treated controls. Furthermore, the former activity was raised to about 6-fold even in the preneoplastic dssues of the skin tissues. On the other hand, the proteolytic activity against casein and insulin decreased to several-fold in the tumor tissues while antitrvpsin activity remained similar in both tumor and controls. Thus, the increase in the activities of plasmInogen activator and plasminlike enzyme appears to occur as a charaderistic to skin cancer and may involve in invasion and metsstasis of the tumor.

키워드

Rat skin tumor ; Proteloysis ; Metasasis

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