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The Presence in Embryo Extract of a Myotrophic Protein That Affects Proliferation and Fusion of Chick Embryonic Myoblasts in Culture

한국동물학회지 1988년 31권 3호 p.207 ~ 217
유병제, 이창호, 곽규봉, 정진하, 하두봉,
소속 상세정보
유병제 ( Yoo Baeng-Jae ) - 대구대학교 생물학과
이창호 ( Lee Chang-Ho ) - 서울대학교 자연과학대학 분자생물학과
곽규봉 ( Kwak Kyu-Bong ) - 서울대학교 자연과학대학 분자생물학과
정진하 ( Chung Chin-Ha ) - 서울대학교 자연과학대학 분자생물학과
하두봉 ( Ha Doo-Bong ) - 서울대학교 자연과학대학 분자생물학과

Abstract


A myotrophic protein that seemed to he eseentiai for the hision of chick embryonic myoblasts in culture was isolated from chick embryo extrad and was found to be identical or at least similar to the iron-transporting protein, transferrin. Embryo extract seemed to contain, in addition to this myotrophic protein, a heat stable protein that inhibits the fusion of myoblasts. Iron seemed to he necessary for myoblasts to fuse and it was supposed that the role of the myotrophic protein m myoblast fusion is to supply iron to the cell. The numher of the myotrophic protein receptors on myoblast surface membrane decreased immediately after the start of myoblast fusion, supposedly due to the decreased need of iron after the fusion once commenced. It was estimated that endocytosis of myotrophic protein took about 10 minutes and one recycling about 2 hours. The accumulation of iron in myoblasts continued linearly with cultre time and endocytosis of the myotrophic protein occured at a constant rate.

키워드

Myoblast fusion ; Myotrophic protein ; Embryo extract

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