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천연소재를 활용한 산화 스트레스성 탈모 세포 모델의 연구 경향

A review for effect of natural compounds on oxidative stress induced-damage in human hair dermal papilla cell

동서의학 2020년 45권 1호 p.49 ~ 55
김유진, 김미려,
소속 상세정보
김유진 ( Kim Yoo-Jin ) - Daegu Haany University College of Korean Medicine Department of Herbal Pharmacology
김미려 ( Kim Mi-Ryeo ) - Daegu Haany University College of Korean Medicine Department of Herbal Pharmacology

Abstract


Objective : In this study, we reviewed previous studies about the effect of natural compounds from herbs on damages by oxidative stress in human hair dermal papilla cell (HDPC), as cellular alopecia model.

Methods : We searched every reports, letters, and review articles through Pubmed and google scholar for 10 years using key words such as oxygen stress, hair, alopecia, and cortical papilla cells.

Resutls : HDPCs were used in experiments of totally four reviewed studies. Also, oxidative stress HDPC decreased cell viability and caused G2/M arrest in HDPC. And researchers reported changes of hair growth-related gene expression in oxidative stressed-HDPC.

Conclusion : These results suggest that oxidative stress could be used the study cellular levels of alopecia by hindering cell growth in HDPC.

키워드

oxidative stress; hair; alopecia; dermal papilla cell; HDPC

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