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家兎摘出 腸管의 血管, 粘膜面 및 漿膜面으로부터 投與한 諸種藥物作用의 比較觀察

Effects of Acetylcholine, Atropine, Epinephrine and Nicotine on the Isolated Intestine of Rabbits by the Administration through Mesenteric Vessels, Serous Membranes and Mucous Membranes

부산의대잡지 1963년 3권 1호 p.29 ~ 34
윤덕상,
소속 상세정보
윤덕상 (  ) - 부산대학교 의과대학 약리학교실

Abstract


The administration of Acetylehline, Atropine, Epinephrine and Nicotine on the mesenteric
vessels,serous membranes and mucous membranes in isolated intestinal preparation of rabbits, using the author´s special apparatus, has revealed the following effects:
(1) Administration of the drugs mentioned produced the most pronounced action in the serous membranes, moderate action in the mesenteric vessels and minimal action in the mucous membranes.
(2) Minimal dosage of Atropine and Nicotine produced, slightly, enhanced contraction and amplitude of intestinal preparation, but large dosage always produced depression.
(3) Administration of Acetylcholine on the mesenteric vessels always caused initial transient decrease of the intestinal tonus before stimulation occurred.
(4) Administration of Epinephrine caused less effect on the mucous membranes and even large dosage could not stop intestinal motility.
(5) Administration of minimal and moderate dosage of Epinephrine? produced stimulation, but large dosage always caused relaxation and cessation of intestinal motility.

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