잠시만 기다려 주세요. 로딩중입니다.

實驗的 心筋炎에 關한 硏究

Studies on Experimental Myocarditis

부산의대잡지 1963년 3권 1호 p.53 ~ 74
홍성문,
소속 상세정보
홍성문 (  ) - 부산대학교 의과대학 내과학교실

Abstract


Normal rabbits were sensitized with normal-duckserum and later received challenging injections with Anti-Rabbit-Heart Duck Serum(Cardiotoxin).Titers of antiserum 80 x (Group 1) and 336 x(Group 2) respectively were used. Subsequently the pathological changes of the cardiovascular and other organ systems were compared with those of a control group (Group 3).
Also, E. C. G., Serum protein, S. G. P. T´. and blood CC. B. C.) changes were observed.
The results are as follows:
1. Edematous metachromatic swelling, fibrinoid swelling,or fibrinoid degeneration were ´observed in the perivascular interstitial tissue of all cases, strongest in group 2, no or very slight changes occurred in the group 3´Control group). These findings were recognized with many different staining methods but the metachromatic change after toluidine blue staining and PAS reaction were most significant.
2. The formation of granuloma (Aschoff body type´) was very significant in all cases of group and 2 but very slight in group 3. The changes were most marked in group 2. Changes did not became significant until 24 hrs. after the challenging injection.
3. Disintegration and dissolution of perivascuular cardiac myofibers occurred in all cases before granuloma formation. Cardiac myofiber lost its proper character, became basophilic and gradually changed tj large basophilic round cell. However, the reduction of DNA and increase of RNA were significant. Only minimal changes occurred in group 3
4. Granulomata were located along branching capillaries and arterioles. Some were fusiform and radial but most were reticular in arrangement, Myogenie large basophilic round cells, large round cells without pyroninophilic granules and various small round cells in the interstitial tissue, which show fibrinoid degeneration, were found in the granulomas. The arteriolar lumen was occluded by endothelial swelling. 5. Vascular changes were similar in heart, lungs,liver, spleen, adrenals and kidneys. The changes were mainly: endothelial swelling, thickening, hyalinization and fibrinoid degeneration of the arteriolar walls. Perivacsluar proteinoid exudation and cell proliferation, but occasionally occlusion of the lumen, plasmastasis, congestion and fibrinoid thrombus formation were seen. Particularly the Masson body of lung, Onion skin appearance of spleen, proliferative glomerulitis and wire-loop lesions of the kidney were observed. The vascular changes seem to be a non-specific allergic reaction due to foreign protein rather than a specific one occurring after anti-rabbit-heart duck serum injection,
6.Generally, E.C.G. changes were slight considering the marked pathologic changes in the heart. Their findings were the elevation or depression of ST segment and low, flat or inverted T,etc..
7. A slight reduction of serum albumin and marked increase in serum globulin, especially of Y-globulin, occurred.
8. The other laboratory findings (S.G.P.T.& C.B.C. )were all within normal limits except slight increase in leucocyte count.

키워드

원문 및 링크아웃 정보

등재저널 정보