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各種胎盤抽出物注射에 因한 血液凝固促進에 關한 實驗的 硏究

Experimental Studies on the Accelerating Effect of Various Placental Extracts Injection upon the Blood Coagulation

부산의대잡지 1963년 3권 1호 p.105 ~ 115
이선익,
소속 상세정보
이선익 (  ) - 부산대학교 의과대학 산부인과교실

Abstract


Recently much attention has been pain too the fact that there are some substances in the placental tissue, which influence blood coagulation regarding the etiology of pregnancy toxemia.
Although the essential form of pregnancy toxemia could not be dissolved clearly yet, it has been mainly explained with various theories such as ischemic theory, hormonal theory and abnormal metabolism theory etc.
It is widely known that thromboplastin are contained in the placental tissue as naca as tic brain and lung tissue and then it is found that such an activated thromboplastin which is contained in the placental substance cause the coagulation in the blood vessels, In Schneider´s theory the important role of thromboplastin in the placental tissue as a blood coagulating factor in the causation of.pregnancy toxemia was stressed.
Kaku who has been investigating the allergic factor in the etiology of pregnancy toxemia examined the effect of various placental extracts injected upon the blood coagulation and gave the name K. P. S. to the polysaccharide substance which was anttbxiy extracted from placenta.-in reference to the effect of polysaccharide stance extracted from Placenta upon the blood coagulation, the author studied the effect of other extracted substance in the placenta upon blood coagulation comparatively.
The results obtained in this study ware as follows: The concentrated water extract injection of human placenta delays the blood coagulation.
1. TheMuted water extract injection, normal saline ox tract injection of human placenta acee I-rate the blood coagulation outstandingly.
3. The thromboplastin of placenta accelerate the blood coagulation as remarkably as the brain thromboplastin do.
4. K. P. S., the substaace of human placental polysaccharide antinogen, accelerate the blood coagulation and it is accomplished by the way that the heat stab! e,aoa-sap onificating, alcohol soluble substance are produced from K. K. S. which is stimulated by K. P. S., and are discharged into the circulating blood stream.

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