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알코올長期投與가 肝臟의 纖維化에 미치는 影響

Studies on the Influences of Ingesting Alcohol for Long Period upon the Fibrosis of the Liver

부산의대잡지 1963년 3권 1호 p.171 ~ 179
최하진,
소속 상세정보
최하진 (  ) - 부산대학교 의과대학 내과학교실

Abstract


The rats were divided into 2 groups, D-group was fed with Daft´s cirrhoaenic diet and normal tap water, while DA-Group was fed with 15 % ethyl alcohol and Daft´s cirrhoaenic diet for 123 days, and then with normal diet and normal tap water for 23 days.
Body weight, serum protein pattern and histological examination of liver and spleen were as follows;
1. Body weight.
Among the cirrhogenic group (D-group) both young rats and relatively mature rats gained weight very slowly, but there was an abrupt increase in body weight when they ware again fed with normal diet for 23 days.
DA-group (15% ethyl alcohol and cirrhoaenic diet) gradually lost body weight while being fed with alcohol & cirrhogenic diet, but immediately
the food was changed into normal diet & tap water, there was an abrupt gain in body weight.
2. Serum Electrophoretic Pattern.
Moderate hypoalbuminemia and hyper-ll-globulinemia was recognized in the D-group, and the serum change persisted throughout the realimentation period. Marked hypoalbuminemia, hyper-3globulinemia and hyper-alpha-2-globulinemia in the DA-group was recognized and persisted through out the realimentation period.
3. Histological examination of liver and spleen. A moderate fibrosis & centrolobular fatty infiltration of the liver in D-group, and marked fibrosis & perilobular fatty ipfiltraion of the liver in DA-group was observed.
4. There was no basic recovery of serum electrophoretic changes or histological findings in the liver, after the gain in body weight & improvement of general condition with realimentation had occurred.

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