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日本腦炎의 急性期 및 恢復期에 있어서의 尿中 17 Ketosteroid 排泄重의 變動에 對하여

The Changes of Urinary 17 Ketosteroid Excretion at Acute and Convalescent Stages of Japanese E-Encephalitis

부산의대잡지 1963년 3권 1호 p.217 ~ 221
이상석,
소속 상세정보
이상석 (  ) - 부산대학교 대학원 의학과 소아과학교실

Abstract


In his important works since 1936, Selye pointed out that if a certain stress were given to living body continuously, there might be some specific relation acted to pituitary - adrenocortical system which named general adaptation syndrome. Selye also noted that specific diseases of adaptation might occur because the adaptation reaction might be occasionally beyond normal limits.
He also stated that the mechanism was responsible for imbalance of excretion of mineral ocorticoid and glucocorticoid, particularly mineral ocorticoid.
As I wrote later, I found that there were some lesions at the anterior pituitary and adrenal cortex in patients of Jap. B. Encephalitis, and I presumed that there might be adranocortical hypofunction especially in severe cases.
So I estimated urinary 17-ketosteroid at acute and convalescent stages for a criteria of adreno_ cortical function, And I observed the changes which was compared to normal urinary 17-ketosteroid excretion in same age group.
The urinary 17-ketosteroid excretion was estimated with the method of Drecter in 26 cases of Jap. B. Encephalitis and 6 cases of normal children as the control at the acute and the convalescent stage.
The results were as follows
1. The urinary 17-ketosteroid excretion in the cases of Jap. B. Encephalitis was reduced markedly in compared with normal children.
2. The convalescent patients also revealed the outstanding decrease of urinary 17-ketosteroid excretion as compared with normal children but it tends to increase somewhat compared with acute stages,

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