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牛水晶體, 硝子體 및 맥락막의 血淸學的 硏究

Serological Studies on Lens, Vitreous and Choroid

부산의대잡지 1965년 5권 1호 p.57 ~ 63
지기업,
소속 상세정보
지기업 (  ) - 부산대학교 의과대학 안과학교실

Abstract


In my previous studies, published in reports I and 11, on the antigenicity of vitreous in comparison´ with the serum and the cerebrospinal fluid (all to be tested were the bovine materials), based on the precipitation reaction in agar and the Middlebrook-Dubos passive hemagglutination test, 1 confirmed that there was a common antigen among them and the Middlebrook-Dubos passive hemagglutination test was more sensitive than the other.
These, confirmations had led me to do further experiments, in which an attempt was made to clarify the properties concerning the organ specificity and the species specificity of ocular tissues such as the lens, the choroid and the vitreous.
Antisera were obtained from rabbits into which the each of the lens, the choroid and the vitreous of bovine was injected separately, and antigens, on the other hand, were prepared in a way that the properly treated materials of above noted bovine tissues were first exposed to sheep erythrocytes and then these sensitized erythrocytes to the antigenic materials were provided for the test after a proper treatment as already being devised in the Middlebrook-Dubos passive hemagglutination test.
Following are the conclusions
1. In the Middlebrook-Dubos hemagglutination test, it was proven that the ectodermal tissues or organs shared the commonly distributed antigens that stimulate the production of bath of the complete and the incomplete antibodies.
2. The organ specificity was especially noteworthy in that the homologous antigen antibody reaction showed titers 2 to 4 times higher than the heterolgous antigen-antibody reaction.
3. Of the autoimmune mechanism in case of the endophthalmitis phacoanaphylactica, it can be deduced that both the precipitating antibody of bivalence and the incomplete antibody of univalence, that have been produced by the group of antibody producing cells which have been stimulated by the inaccessible antigen of the lens protein will participate in the mechanism.

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