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Adrenocrticotropic Hormone(ACTH, corticotropin) 抗體의 實驗的硏究

Experimental Studies on the Adrenocorticotropic Hormone (ACTH, corticotropin) Antibody

부산의대잡지 1966년 6권 1호 p.55 ~ 70
서휘수,
소속 상세정보
서휘수 (  ) - 부산대학교 의과대학 미생물학교실

Abstract


ACTH mixed with Freund´s complete adjuvant and sensitized rabbits and guinea pigs. After two weeks from the last sensitizing injection experimental animals were bled partially to test the ACTH circulating antibodies by precipitation, complement fixation, passive hemagglutination, hemagglutination inhibition, hemolytic, hemolytic inhibition, antiglobulin reactions and neutralization test for biological activity of the ACTH by modified Thorn test. The same animals were used again for testing active skin test and anaphylactic shock by eliciting injection with ACTH as an antigen, and the following results were obtained.
1. The sera of ACTH sensitized rabbits were showed negative reactions by the precipitation and complement fixation reactions, but positive reactions by the passive hemagglutination, hemolytic and antiglobulin reactions.
2. The sera of ACTH sensitized guinea pigs, were showed negative reaction by the precipitation, but positive reactions by the complement fixation and other serological reactions.
3. The sera from ACTH sensitized rabbits and guinea pigs contained neutralizing antibody against biological activity of the ACTH.
4. Intensities of the skin reactions and anaphylactic shock may seem parallel in the ACTH sensitized guinea pigs.
5. The positive results of the blocking tests by passive hemagglutination inhibition, hemolytic inhibition and Plausnitz-KU.istner reactions may indicate the specific antigen-antibody reaction to the ACTH.

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