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各種 Hormone 狀態에 있는 白鼠摘出子宮에 對한 5-Hydroxytryptamine의 作用

Action of 5-Hydroxytryptamine on the Isolated Uteri of Rats in Various Hormonal States

부산의대잡지 1966년 6권 1호 p.71 ~ 80
양국신,
소속 상세정보
양국신 (  ) - 부산대학교 의과대학 약리학교실

Abstract


The author studied the action of 5-hydroxytryptamine (5-HT) on isolated uteri of rats in various hormonal states and obtained the following results:
1. The motility of isolated uteri from mature rats was inhibited by 5-HT in high concentrations, but stimulated in lower concentrations. This - stimulatory action of 5-HT was blocked by lysergic acid diethylamide (LSD) as well as phenoxybenzamine.
2. In immature rat uteri, the inhibitory effect of 5-HT was augmented and its stimulatory effect was markedly diminished.
3. The motility of isolated uteri from estrous rats, from pregnant rats and from immature rats pretreated with estrogen was consistently stimulated by 5-HT. These stimulatory effects were not blocked by phenoxybenzamine, but were blocked by LSD.
4. The motility of isolated uteri from immature rats pretreated with progesterone was consistently inhibited by 5-HT.
5. In isolated uteri from mature rats pretreated with reserpine, the inhibitory action of 5-HT was markedly diminished.

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