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히스타민을 주사한 토끼의 혈액량

Effect of Histamine on Blood Volume in Rabbits

부산의대잡지 1966년 6권 1호 p.85 ~ 88
李花得, 번정식, 具鐵會, 成虎慶,
소속 상세정보
李花得 (  ) - 부산대학교 의과대학 생리학교실
번정식 (  ) - 부산대학교 의과대학 생리학교실
具鐵會 (  ) - 부산대학교 의과대학 생리학교실
成虎慶 (  ) - 부산대학교 의과대학 생리학교실

Abstract


The effect of histamine on plasma volume, blood volume and plasma protein were studied in rabbits. Sixteen normal rabbits were served as control and in fifteen rabbits, effect of histamine was observed. T-1824 was administered intravenously. Plasma volume was measured after ten minutes of equilibration.
Arterial´ blood samples were collected by left heart puncture and assayed for T-1824 and plasma specific
gravities.
The following results were obtained.
1. Histamine injection resulted in a remarkable decrease in total plasma protein and it was interpreted as
leakage of plasma protein through the capillary wall caused by the increased capillary permeability.
2. Histamine produced decrease of circulating plasma volume as well as blood volume and. increase of hematocrit ratio significantly as compared to control.
3. Plasma protein and plasma volume imbalance effecting hypovolemia caused by the histamine action were discussed.

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