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일측 폐절제가 신장적출 토끼 혈장내 이뉼린 소실율에 미치는 영향

The Effect of Unilateral Pneumonectomy on the Disappearance Rate of Inulin From the Plasma of Nephrectomized Rabbits

부산의대잡지 1969년 9권 1호 p.7 ~ 12
成虎慶, 金光洵, 韓錫相,
소속 상세정보
成虎慶 (  ) - 부산대학교 의과대학 생리학교실
金光洵 (  ) - 부산대학교 의과대학 생리학교실
韓錫相 (  ) - 부산대학교 의과대학 생리학교실

Abstract


Disappearance rate of injected inulin from the plasma as well as the effect of unilateral pneumonectomy on the rate were studied in nephrectomized rabbits by means of a single injection method.
Both the control and pneumonectomized rabbits were sacrificed after 5. 30. 60. 90. and 120 minutes of inulin injection. The concentration of Inulin in the serial arterial samples obtained by left heart puncture were assayed by the resorcinol method without alkali treatment of Schreiner.
In the pneumonectomized rabbits, pneumonectomy was performed by the aid of the resection of right third rib under the urethane anesthesia.
The following results were obtained
l. Inulin concentration in plasma water, Ct was obtained by the sum of three exponential terms of time in both of control and pneumonectomized rabbits -m1t -m2t -m3t Ct=a1e + a2e + a3e and its theoretical basis was derived by the equation of Flexner.
2. In the pneumonectomized rabbits the disappearance rate of first term was smaller than that of control rabbits, suggesting a limitation to the lessor circulation.On the other hand the disappearance constant of second and equilibrium curve were increased by
pneumonectomy suggesting a diffusion of high inulin concentration left in plasma water.
3. The animal subjected to pneumonectomy showed a somewhat decrease in theoretical volume of inulin distribution.

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