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過炭酸症 家兎에 있어서 心筋細胞의 緩衡能力과 心電圖에 關한 實驗的 硏究

Experimental Studies on Buffer Capacity of Cardiac Muscle and Electrocardiogram of :hypercapnic Rabbits

부산의대잡지 1969년 9권 2호 p.105 ~ 115
최락상,
소속 상세정보
최락상 (  ) - 부산대학교 의과대학 소아과학교실

Abstract


The intracellular pH was determined from the cardiac muscles of 15 normal, 17 hypercapnic and 8 hyperkalemic rabbits, using 5, 5-dimethyl-2, 4-oxazolidinedione (DMO) method.
The relationship between intracellular and extracellular hydrogen ion concentrations and between intracellular gnd extracellular buffer capacities were observed.
Electrocardiograhic changes were studied on the hypercapnic rabbits which were produced by administration of 10 to 2070 carbon dioxide-oxygen mixtures and on the hyperkalemic rabbits which were produced by intravenous infusion of 1(C1 solution.
The results were obtained as follows;
1) Normal acid-base parameters of blood were pH 7.46, H+ concentration 35 nM/L, Pco2 30 mmHg, HC03- concentration 20. 4 mEq/L and those of cardiac muscles were pH 7. 04, H+ concentration 91 nM/L, HCO3; concentration 9.2 mEq/L.
2) Buffer curve in acute hypercapnic rabbits had a slope of 31. 2 mEq/L, pH and that of cardiac muscle 17.6 mEq/L, pH.
3) H+ concentration ratio between blood and cardiac muscle was 1: 2. 60 in normal rabbits, whereas it was 1:2.76 in hypercapnic rabbits. The relationship between H+ concentration of blood and cardiac muscle was expressed in an equation of(H+)i=-19.5+3. 05(H+)e.
4) Acute hyperkalemia induced acidosis in cardiac muscle as well as in blood.
5) It seemed that the electrocardiographic changes in acute hypercapnic rabbits were mainly correlated with the increase in plasma concentration of potassium rather than hydrogen ion.

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