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개구리 心臟內 Inorganic Phosphate 遊離에 對한 交感神經 β-receptor 封鎖劑의 作用

Action of Beta-Adrenergic Blockades on the Liberation of Inorganic Phosphate in the Isolated Frog Heart

부산의대잡지 1969년 9권 2호 p.155 ~ 159
崔信貞, 李鐘范, 許潤,
소속 상세정보
崔信貞 (  ) - 釜山大學校 醫科大學 藥理學敎室
李鐘范 (  ) - 釜山大學校 醫科大學 藥理學敎室
許潤 (  ) - 釜山大學校 醫科大學 內科學敎室

Abstract


The authors compared the ability of a number of sympathomimetic amines to increase contractility of the frog heart and the liberation of inorganic phosphate. It was-found that adrenaline, noradrenaline and isoprotermol, in doses which had a positive isotropic action on the heart, also increased the liberation of inorganic phosphate and obtained the following results.
i. Isoproterenol, adrenaline and noradrenaline´produced increase of the liberation of inorganic phosphate of frog heart.
2. Propranolol, Pronethalol, DCI, MJ 1999 and MJ 1998 reduced the liberation of inorganic phosphate of frog heart.
3. The chronotropic and isotropic actions and the increase of the liberation of inorganic phosphate of
isoproterenol, adrenaline, and noradrenaline was inhibited by the administration of beta adrenergic blockades in the following order.
Propranolol )Pronethalol,>DCI >MJ 1999 )MJ 1998.

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