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경계선이 피부에 미치는 영향에 관한 실험적 연구

Experimental Studies on the Effect of Grenz Ray on the Skin

부산의대잡지 1970년 10권 2호 p.113 ~ 123
정태안,
소속 상세정보
정태안 (  ) - 부산대학교 의과대학 피부과학교실

Abstract


The experiments were carried out to observe the effect of grenz ray on the skin. The animals used in this studies were adult rabbits of both sexes, and divided into three groups. The first group with single dose of grenz ray irradiation, the second group with six every other day or every third day irradiation, and the third group with fourty successive doses irradiation were performed, and then gross, histologic, and histochemical observations of DNA, RNA, and glycogen were made periodically after grenz ray irradiation.
The results thus obtained were discussed and summarized as follows:
1. The rabbits irradiated with single dose of grenz ray revealed no gross changes, but histologically vacuolization of prickle calls, hyperkeratosis and acanthasis,and histochemically decreased DNA, and increased RNA and glycogen were observed after grenz ray irradiation, but these changes were returned to preirradiated condition by the passage of time.
2. The rabbits treated with six doses of grenz ray irradiation showed no gross changes, but histologically hyperkeratosis, atrophy of the epidermis and atrophy or partial loss of hair follicles, and histochemically decreased DNA, and increased RNA and glycogen were observed.
3. The rabbits treated with fourty successive doses of grenz ray irradiation manifested erythema, thickening of the skin, retarded hair growth, alopecia and erosion, and histologically hyperkeratosis, loss of the epidermis, acanthosis, changes of nuclei, cellular infiltration, atrophy and loss of hair follicles, and collagen degeneration were observed.
On the basis of the above it is suggested that changes in DNA, RNA and glycogen occur shortly after grenz ray irradiation even if gross and histologal changes are not visible, and these changes are reversible. The gross and histological changes observed are secondary phenomenon due to decreased DNA and increased RNA and glycogen, but massive doses of grenz ray irradiation cause irreversible damage to the shin.

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