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Tetracycline이 토끼 적혈구막의 포타슘투과에 미치는 영향 Effect of Tetracycline on the Potassium Permeability of the Rabbit Erythrocyte Membrane

부산의대잡지 1975년 15권 1호 p.309 ~ 315
김용근,
소속 상세정보
김용근 (  ) 
부산대학교 의과대학 생리학교실

Abstract


The effects of tetracycline on the potassium permeability of the rabbit erythrocyte membrane are investi­gated and the results are summarized as follows.
1. Tetracycline causes the efflux of K+ across the rabbit erythrocyte membrane. The osmotic resistance of tetracycline-treated erythrocytes is diminished. This diminution of the osmotic resistance is more pronounced by increasing concentration of tetracycline and longer incubation time.
2. Cysteine and glutathione have little influence on the diminution of osmotic resistance induced by tetracycline.
3. The addition of PCMB and DNFB augments K outflux slightly while EDTA and EGTA have no effect on the increase in K outflux by tetracycline.
4. Tetracycline inhibits Na+-K+ ATPase activity of ghosts cells of the rabbit. The inhibition of Na´-K´ ATPase activity by tetracycline is not prevented by an addition of cysteine in the incubation medium.

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