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간손상 백서의 동대사에 관한 연구 Study on Copper Metabolism with Radio Copper(64-Cu) on the Chemically Induced Liver injury in the Rats

부산의대잡지 1977년 17권 2호 p.139 ~ 148
김동수,
소속 상세정보
김동수 (  ) 
부산대학교 의과대학 내과학교실

Abstract


The experimental study was carried out to clarify for the pathogenesis of Wilson´s disease in man. The animal were used 80 male rats Sprauch dawly weighing about 100-1 SO gm. The experimental animals were divided into three experimental group. The first group was treated by copperchloride alone intraperitoneally five times a week for three months, the second group was treated with carbon tetrachloride alone sub-cutaneously twice a week for three months and the third group was given first two months as first group and after that combined procedure with the one and the two groups for one month. The control group was given normal saline as same as above frequency and routes.
After the above mentioned process completed, administerd intravinously on the tail vein of the rats 20 mCi of 64-Cu before sacrificed. And sacrificed ten-minutes, thirty-minutes, 2.5 hrs, ten hours and fourty hours after injection of radio-copper and measured the radioactivity from the plasma, liver, brain and kidney tissues under dry mass preparation.
The results were observed as follows;
1. In the copper alone and both copper and carbon tetrachloride the radioactivity of the liver tissue was significantly higher than in the rats given carbone tetrachloride alone and control rats.
2. In the rats given copper alone and both copper and carbone tetrachloride the plasma radioactivity was significantly lower at 10 hours after the injection of radiocopper than that in the rats given carbon tetrachloride alone and control rats.
3. In all the experimental groups of the rats the radioactivity of the brain tissue was significantly lower than in the control rats at 10 hours after injection of the radiocopper.
4. In the experimental groups of the rats the radioactivity of the kidney tissue was significantly higher than that in control rats at 2.5 hours after injection of the radiocopper, while in the radioactivity of its was rather significantly lower than that in the latter 10 hours after injection of radiocopper.

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