Hexachlorophene의 Mannich Bases 합성 및 항미생물작용에 관한 연구
Studies on the Synthesis of Mannich Bases of Hexachlorophene and their Antimicrobial Activities
산업미생물학회지 1973년 1권 1호 p.43 ~ 50
金鍾浩, 裵武, 李啓準,
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金鍾浩 ( )
慶熙大學校 文理科大學 化學科
裵武 ( )
韓國科學技術硏究所 應用微生物硏究室
李啓準 ( )
韓國科學技術硏究所 應用微生物硏究室
KMID : 0366119730010010043
Abstract
Thirty-three Mannich bases of 2, 2´-methylene bis (3, 4, 6-trichlorophenoxy-acetic acid)were synthesized hexachlorophene as potential antimicrobial agents and tested against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Trichophyton rubrum, Microsporum gypseum, Epidermophyton floccosum, Aspergillus niger and Aspergillus oryzae in vitro. It was found that:1) 2, 2´-Methylene bis [α-(3, 4, 6-trichlorophenoxy)-β-(N, N-diethylamino) propionic acid] and 2, 2´-methylene bis [α-(3, 4, 6-trichlorophenoxy)-β-(N, N-dimethynlamo)propionoic acid] were active against Staphylococcus aureus and Bacillus subtilis at the concn. of 1 ㎍/ml respectively; 2) 2, 2´-Methylene bis [α-(3, 4, 6-trichlorophenoxy)-β-(m-hydroxy-p-carboxyphenylamino) propionic acid] and 2, 2´-methylene bis [α-(3, 4, 6-trichlorophenoxy)-β-(cyclohex-ylamino) propionic acid] were active against Trichophyton rubrum at the concn. of 2 ㎍/ml respectively; 3) 2, 2´-Methylene bis [α-(3, 4, 6-trichlorophenoxy)-β-(m-hydroxy-p-carboxyphenyl-amino) propionic acid] and 2, 2´-methylene bis [α-(3, 4, 6-trcihlorophenoxy)-β-(piperidino) propionic acid] were active against Microsporum gypseum at the concn. of 2 ㎍/ml respectively; 4) 2, 2´-Methylene bis [α-(3, 4, 6-trichlorophenoxy)-β-(m-hydroxyphenylamino) propionic acid], 2, 2´-methylene bis [α-(3, 4, 6-trichlorophenoxy)-β-(m-hydroxy-p-carboxy phenylamino) propionic acid], 2, 2´-methylene bis [α-(3, 4, 6-trichlorophenoxy)-β-(o-chlorophenylamino) propionic acid], 2, 2´-methylene bis [α-(3, 4, 6-trichlorophenoxy)-β-(o-chloro-p-nitrophenylamino) propionic acid], 2, 2´-methylene bis [α-(3, 4, 6-trichlorophenoxy)-β-(methylamino) propionic acid], 2, 2´-methylene bis [α-(3, 4, 6-trichlorophenoxy)-β-(hydroxylamino) propionic acid], 2, 2´-methylene bis [α-(3, 4, 6-trichlorophenoxy)-β-(cyclohexylamino) propionic acid], 2, 2´-methylene bis [α-(3, 4, 6-trichlorophenoxy)-β-(morpholino) propionic acid], 2, 2´-methylene bis [α-(3, 4, 6-trichlorophenoxy)-β-(p-sulfophenylamino) propionic acid] and 2, 2´-methylene
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