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ACTH 또는 振動 緊迫이 비타민 A 缺乏 白鼠의 胃粘膜에 미치는 影響

THE EFFECTS OF ACTH OR OF "SHOKING STRES" ON THE GASTRIC MUCOSA OF VITAMIN A DIFFICIENT RATS

소아과 1964년 7권 2호 p.6 ~ 32
문영은,
소속 상세정보
문영은 (  ) - 연세대학교 의과대학 생화학교실 연세대학교 의과대학 소아과학교실

Abstract


1. The rats fed on vitamin A free diet for one month to three months did not produce gastric lesions However, when the ACTH was administered. small superficial ulcers were demonstrated in the mucosa of the glandular stomach both in the study group and control group. The extent and incidence of gastric lesions were more pronounced in the study group.
2. Application of mechanical shaking caused gastric ulcers in the glandular portion of stomach and fore-stomach and it was more pronounced in the study group. The severity and incidence of gastric lesion was parallel to the frequency and duration of the application of shaking stress. The response to the "shaking stress" was more pronounced among the young rats.
3. The urinary 17-ketosteroid excretion was increased when rapid acting ACTH or stronger shaking stress were applied in both study and control groups However, the long acting ACTH gel or milder "shaking stress" did not produce any remarkable change of urinary 17-ketetosteroid excretion.
4. Twenty-four hour uropepsin output increased four to five times among the study group after administration of rapid acting ACTH and two to three times after the application of mechanical shaking.
5. When ACTH was administered to the study group.24 hours uropepsin output increased four to five times of that before the administration of ACTH. The application of "shaking stress" also caused twa to three times more excretion than before the application of "shaking stress". The control grc -ip did not show any significant increase in uropepsin excretion with the administration of ACTH or application of "shaking stress".
6. The growth of study group began to decline about one month after the initiation of vitamin A free diet while the control group continued to grow. This was more marked among the young rats The young rats born of mother rat fed on vitamin A free diet showed remarkable decline of growth. .

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