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大腦皮質에 있어 尿量에 影響을 미치는 部位에 關한 實驗的硏究

An Experimental Study on The Inflnenco of The Carebral Cortex upon Urinary Output

소아과 1969년 12권 10호 p.11 ~ 21
이종만,
소속 상세정보
이종만 (  ) - 서울대학교 의과대학 소아과학교실

Abstract


Many studies have been reported on the role of hypothalamus as the regulating center of the water and electrolyte balances also, there have been many experimental assertions on direct connections of nerve fibers between hypothalamus and cerebral cortex.
Author experimentally observed the changes of the urinary output by the osmotic stimulation on the 23 areas of cerebral cortex which author divided.
Korean white male rabbits weighing 1.8 kg. were used as experimental animals, and 2% sodium
chloride solution administered per os for 3 times by 1 lour interval before osmotic stimulation.
The amount of sodium chloride solution administered corresponds to 5% of* individual body weight. The osmotic stimulation on the cerebral cortex with 2% hypersonic sodium chloride solution was
followed and the measurement on the urine was made by 5 min. interval.
The following findings were observed.
1. A rapid and marked reduction of urine output was observed in 7 rabbits by the osmotic stimulation with 2% hypertonic sodium chloride solution on the "a" area
2. A rapid and marked reduction of urine output was observed in 7 rabbits by the osmotic stimulation with 29ol hypertonic sodium chloride solution on the "L´ area
3. A rapid and marked reduction of urine output was also observed in 7 rabbits by the osmotic stimulation with 2% hypersonic sodium chloride solution on the "xb area.
4. No remarkable changes in the urine output were observed by the osmotic stimulation on the other 20 areas of cerebral cortex.
Above mentioned experimental findings lead us to such conclusion that possible connections exist between hypothalamus and a, 1 and x area of cerebral cortex and these areas might be correspond to the cingulate gyros, the anterior parts of the temporal lobe and the orbito-frontal area respectively.
In addition these areas are considered to be related with the action of osmoreceptor either directly or indirectly.

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