잠시만 기다려 주세요. 로딩중입니다.

幼若動物 肝組織內의 Cholesterol 合成에 關하여

A Study on th Biosynthesis of Cholesterol in the Rat Liver Tissue

소아과 1970년 11권 1호 p.1 ~ 3
소속 상세정보
成樂潤/Sung, N. Y.

Abstract


Among the various factors to cause the low serum cholesterol contents of new-borns, which usually amounts only half the value of the maternal level, actove metabolisms in younger animals, together inmature biosynthetic activity could be proposed. The present author, therefor, managed to run a experiment employing Acetate-1-C14 incorporation test in the liver of young rat at its various times after the birth, and obtained results as follows=
The in vitro ineMporatigm of acetate-l-CS into liver cholesterol was traced in new-born rats immediately, 10 days and 2 months after the birth as well as in the maternal adults of those animals. The rate of cholesterol biosynthesis in the liver was 172-245 cpm/g tissue immediately after the bith,r increasing to 728 cpm/g tissue after 2 months. The rate in the maternal adults was 650 cpm/g tissue, a slightly lower value than that of 2 month-old animal, but still higher than that immediately after the birth by over 150%. It seems, therefore, that the difference in the serum cholesterol level between new-born and maternal sides results partly from the difference in the biosynthetic rate of cholesterol in the liver of the animal, as is shown in this study.

키워드

원문 및 링크아웃 정보

등재저널 정보

KoreaMed
KAMS