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小兒 腦脊髓液內에 있어서 投與 Chloramphenicol 含量의 變動

Chloramphenicol Levels in Cerebrospinal Fluid of Purulent Meningitis Children

소아과 1970년 13권 1호 p.29 ~ 31
박민화,
소속 상세정보
박민화 (  ) - 전남대학교 의과대학 소아과학교실

Abstract


The level of chloramphenicol in cerebrospinal fluid was studied in 10 cases of purulent meningitis with single intramuscular injection of chloramphenicol 100 mg/kg.
The level of chloramphenicol in cerebrospinal fluid reached maximal concentration two hours after the intramuscular injection, maintained the effective level until 5 hours, and then progressively decreased.
The level of cerebrospinal fluid chloramphenicol was about a half that of plasma level.
It was shown from the above data that intramuscular injection of chloramphenicol should be repeated with interval of five to six hours for maintenance of effective therapeutic level.

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KoreaMed
KAMS