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소아 설사증 치료에 있어서 Lomotil의 효과 A Clinical Study using Lomotil for Nonspecific Diarrhea in Children

소아과 1977년 18권 4호 p.46 ~ 51
정광연, 안민, 손명현, 박복련,
소속 상세정보
정광연 (  ) 
연세대학교 의과대학 소아과학교실

안민 (  ) 
연세대학교 의과대학 소아과학교실
손명현 (  ) 
연세대학교 의과대학 소아과학교실
박복련 (  ) 
연세대학교 의과대학 소아과학교실

Abstract


Lomotil, a brand of Diphenoxylate hydrochloride with Atropine sulfate, is a remedy for the symptomatic control of diarrhea.
Clinical trials with Lomotil in 120 cases of non-specific diarrhea in infancy and early child-hood have been done for evaluation of effectiveness.
The patients ranged in age from 4 months to 4 years. They were divided into 3 groups. Group I : Lomotil alone (40 cases).
Group I : Lomotil with Ampicillin (40 cases).
Group 1 Kaoline alone (40 cases).
Dosages depended on age and physical state and submitted to journals cited.
The response to the drugs was classified as follows; "Excellent" if improvement occured within 24 hours, "Good´ within 48 hours, "Fair" within 96 hours, and "Poor´ if no improvement was seen after 96 hours of treatment.
From this study it was seen that among the 40 patients treated with Lomotil alone, 87.5% showed an excellent to fair response, while poor results were obtained in only 12.596 of the cases.
In the second group, added with Ampicillin, excellent to fair results were obtained in 90%, while poor results were obtained in only 10% of cases.
The third group i.e. treated with Kaoline alone, showed excellent to fair response in only 60% of cases.
Althrough Kaoline has been widely used as a non-specific measure in the treatment of diarrhea, the results of this study showed that "Lomotil" yielded more effective response in the treatment of non-specific diarrhea.
Although side effects were uncommon and minimal, there were 7 patients who revealed mild abdominal distension (6 cases) and restless (1 case) under I year of age. These patients returned to normal after the medication was discontinued.

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