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조현병 환자와 양극성 I형 장애 환자에서 인지조절 결함의 비교

Comparison of Cognitive Control Deficits in Patients with Schizophrenia and Bipolar I Disorder

신경정신의학 2020년 59권 3호 p.236 ~ 242
진보현, 윤혜림, 배민재, 원승희,
소속 상세정보
진보현 ( Jin Bo-Hyun ) - Kyungpook National University School of Medicine Department of Psychiatry
윤혜림 ( Yun Hye-Rim ) - Woorisaemyung Hospital Department of Psychiatry
배민재 ( Bae Min-Jae ) - Kyungpook National University School of Medicine Department of Psychiatry
원승희 ( Won Seung-Hee ) - Kyungpook National University School of Medicine Department of Psychiatry

Abstract


Objectives: Cognitive control is an adaptive behavior that requires goal-maintaining ability in response to a dynamically changing environment. This study examined the differences and profiles of cognitive control deficits to determine if cognitive control could be a possible candidate as a common pathophysiologic marker of schizophrenia and bipolar disorder.

Methods: Three groups were included in this study: remitted schizophrenia patients (n=56), patients in euthymic states of bipolar I disorder (n=52), and healthy control (n=57), who were matched on sex, age, years of education. The Continuous Performance Test of the AX version (AX-CPT) was used to evaluate the cognitive control function. Intelligence, psychopathology, and psychomotor speed were also examined. The degree of cognitive control deficits was assessed by the commission error rates, correct response times, and the d′ values.

Results: Both patient groups performed worse in the AX and BX trials than the healthy control. Both patient groups showed a delayed response in all trials than the healthy control. The d′ value was the highest in the healthy control group, but there were no significant differences between the two patient groups. The profile of defects in the two patient groups was the same, with the BX trial having the highest defects in the order of the AX, BY, and AY trials.

Conclusion: These findings indicate that cognitive control is impaired in patients with schizophrenia and bipolar I disorder. Impairments in cognitive control are likely to be a possible shared pathophysiological marker for both disorders.

키워드

인지조절; 지속수행검사; 조현병; 양극성 I형 장애
Cognitive control; Continuous performance test; Schizophrenia; Bipolar I disorder

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