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식이유도 비만 마우스에서 대마 추출물의 체중 감량 효과에 대한 예비 연구

A Pilot Study on the Effect of Cannabis Extract on Weight Loss in Diet-induced Obese Mice

신경정신의학 2020년 59권 3호 p.260 ~ 267
Jang Yoo-Jin, 임신원, 우숙영, 김수연, 김도관,
소속 상세정보
Jang Yoo-Jin ( Jang Yoo-Jin ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Psychiatry
임신원 ( Lim Shinn-Won ) - Sungkyunkwan University School of Medicine SAIHST
우숙영 ( Woo Sook-Young ) - Sungkyunkwan University School of Medicine Samsung Medical Center Statistic and Data Center
김수연 ( Kim Su-Yeon ) - Samsung Biomedical Research Institute Center for Clinical Research
김도관 ( Kim Doh-Kwan ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Psychiatry

Abstract


Objectives: This study aimed to investigate the pharmacological effect of cannabis extract on weight loss in diet-induced obese mice.

Methods: A total of 12 C57BL/6 male mice (Orient Bio), aged 6 weeks, were fed a high-fat diet for 13 weeks to construct a diet-induced obesity model. During the following 5 weeks, diet-induced obese mice were daily administered cannabis extract or sesame seed oil orally along with the high-fat diet. The body weight of each subject was measured weekly. Venous blood was drawn for biochemistry, enzyme-linked immunoassay, and oral glucose tolerance test before and after treatment. Body fat was measured by dual-energy X-ray absorptiometry, and the mesenteric adipose tissue was also measured after sacrifice. We used exact Wilcoxon's two-sample analyses and generalized estimating equations to test the differences between the cannabis-treated group and control.

Results: There was significant weight loss (p=0.009) observed in the cannabis-treated mice compared to the control group after 5 weeks of treatment. High-fat diet-induced glucose intolerance in the cannabis-treated group was significantly ameliorated (p=0.032), whereas there were no profound differences between the two groups in terms of other physiological markers, including corticosterone level.

Conclusion: This study shows that orally administered cannabis extract had a pharmacological effect of weight loss in diet-induced obese mice. This weight loss might be attributed to an increase in energy expenditure and regulation of glucose homeostasis.

키워드

대마; 체중감소; 비만; 식이유도 비만 마우스; 포도당대사 항상성
Cannabis; Weight loss; Obesity; Diet-induced obese mouse; Glucose metabolism homeostasis

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