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기분조절제로 인한 인지기능 부작용이 동반된 양극성 기분장애 환자의 임상적인 특징: 아시아의 정신작용약물 처방 경향 연구(REAP-BD Survey) 중 국내 자료 활용

Clinical Characteristics of Bipolar Disorder Patients with Mood Stabilizer-Induced Cognitive Side Effects findings from the REAP-BD Survey in Korea

신경정신의학 2020년 59권 3호 p.277 ~ 284
신희현, 최진희, 소형석, 최하연, 박용천, Tan Chay Hoon, Lin Shih-Ku, Shinfuku Naotaka, 박선철, 김기원,
소속 상세정보
신희현 ( Shin Hi-Hyun ) - Veteran Health Service Medical Center Department of Psychiatry
최진희 ( Choi Jin-Hee ) - Veteran Health Service Medical Center Department of Psychiatry
소형석 ( So Hyung-Seok ) - Veteran Health Service Medical Center Department of Psychiatry
최하연 ( Choi Ha-Yun ) - Veteran Health Service Medical Center Department of Psychiatry
박용천 ( Park Yong-Chon ) - Hanyang University Guri Hospital Department of Neuropsychiatry
 ( Tan Chay Hoon ) - National University Hospital Department of Pharmacology
 ( Lin Shih-Ku ) - Taipei City Hospital Psychiatric Center
 ( Shinfuku Naotaka ) - Seinan Gakuin University School of Human Sciences Department of Social Welfare
박선철 ( Park Seon-Cheol ) - Inje University Haeundae Paik Hospital Department of Psychiatry
김기원 ( Kim Ki-Won ) - Veteran Health Service Medical Center Department of Psychiatry

Abstract


Objectives: This study aimed to identify differences between bipolar disorder patients who experienced cognitive side effects and those who did not experience cognitive side effects due to prescription of mood stabilizers.

Methods: This study analyzed 350 Korean adults who were diagnosed with bipolar disorder and prescribed mood-stabilizing drugs. The patients were divided into two groups?patients who experienced cognitive side effects and those who did not experience cognitive side effects. We also compared the demographic and clinical characteristics between both groups.

Results: The number of patients with an untreated illness longer than 1 year was higher in the group of patients who experienced cognitive side effects compared to the group of patients who did not experience cognitive side effects. Further, the number of patients with manic symptoms at onset was higher in the group of patients who experienced cognitive side effects compared to the group of patients who did not experience cognitive side effects. In addition, the proportion of patients in remission was higher in the group of patients who experienced cognitive side effects compared to the group of patients who experienced no cognitive side effects. However, there was no significant difference regarding the type of mood stabilizer used between the groups. On the other hand, more people experienced cognitive side effects as the valproic acid dosage increased.

Conclusion: Our findings suggest that there are clinical and demographic differences between people who experienced cognitive side effects and those who did not experience cognitive side effects due to prescription of mood stabilizers.

키워드

양극성 장애; 기분조절제; 인지기능 부작용
Bipolar disorder; Mood stabilizer; Cognitive side effect

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